Agilent Technologies 8000 Series Manuel de l'opérateur Page 1

Agilent Technologies Agilent 8000 Dissolution Sampling StationOperator’s Manual

10 8000 Operator’s Manual TablesTable 25. Manual Sampling Options 95Table 26. Volume Accuracy Parameter Options 101Table 27. Print Selections Options

100 8000 Operator’s Manual4 Operating the 8000 15 Upon completion of the priming cycle, the following screen displays: 16 Press OPEN VALVES. The first

Operating the 8000 48000 Operator’s Manual 101 Checking the Calibration - Volume AccuracyCheck the calibration by running a short sampling procedure a

102 8000 Operator’s Manual4 Operating the 8000 Daisy ChainingA series of dissolution apparatus and 8000s can be started at the same time using one 800

Operating the 8000 48000 Operator’s Manual 103 Each unit starts running the program you entered.Printer Operation and CommunicationsUse print options

104 8000 Operator’s Manual4 Operating the 8000 Following is a description of the Print Selections screen options:Table 2 7 Print Selections OptionsOpt

105Agilent TechnologiesAgilent 8000 Dissolution Sampling StationOperator’s Manual 5Maintenance and TroubleshootingPreventive Maintenance 106Report Cen

106 8000 Operator’s Manual5 Maintenance and Troubleshooting Preventive MaintenancePerform the following maintenance when necessary:Clean System with P

Maintenance and Troubleshooting 58000 Operator’s Manual 107 5 On the 8000, press CLEAN SYSTEM. The Cleaning Systems Selections screen displays. To sta

108 8000 Operator’s Manual5 Maintenance and Troubleshooting Start ImmediatelyFrom the Cleaning Systems Selections screen, select option 1, Start Clean

Maintenance and Troubleshooting 58000 Operator’s Manual 109 Auto Clean. 3 Select option 2, Program Auto Clean. The Program Auto Clean Variables scree

11Agilent TechnologiesAgilent 8000 Dissolution Sampling StationOperator’s Manual 1SafetyElectrical Hazards 12The Agilent 8000 has been designed and te

110 8000 Operator’s Manual5 Maintenance and Troubleshooting 4 Select each option and enter the appropriate parameters as necessary based on tubing len

Maintenance and Troubleshooting 58000 Operator’s Manual 111 • the peristaltic pump reverses and the cleaning solution is pulled back through the sampl

112 8000 Operator’s Manual5 Maintenance and Troubleshooting 9 Upon completion of the cleaning process, the 8000 dispensing arm and the Apparatus 3 / 7

Maintenance and Troubleshooting 58000 Operator’s Manual 113 12 Install the new seal into the syringe port, making sure that it lays flat in the bottom

114 8000 Operator’s Manual5 Maintenance and Troubleshooting 5 Enter 100 and press ENTER. The syringes fill completely with cleaning solution.6 Allow t

Maintenance and Troubleshooting 58000 Operator’s Manual 115 System Cleaning Procedure with Syringe Pump and Filter Changer (optional)To clean the 8000

116 8000 Operator’s Manual5 Maintenance and Troubleshooting 6 Enter the following parameters:7 Press ESC until the Ready screen displays.8 Press START

Maintenance and Troubleshooting 58000 Operator’s Manual 117 6 Repeat Steps 4 and 5 a minimum of four times to completely expel the cleaning solution f

118 8000 Operator’s Manual5 Maintenance and Troubleshooting 9 Press ESC to return to the Manual Operations screen.10 Select option 5, Turn On R-M Pump

Maintenance and Troubleshooting 58000 Operator’s Manual 119 Report Center Impact PrinterThe following is helpful information for using your impact pri

12 8000 Operator’s Manual1Safety Electrical HazardsThe 8000 contains electrical circuits, devices, and components operating at dangerous voltages. Con

120 8000 Operator’s Manual5 Maintenance and Troubleshooting If you get ribbon ink on the printer’s plastic cover, remove it immediately. Once dried, i

Maintenance and Troubleshooting 58000 Operator’s Manual 121 13 Replace the paper roll cover. If the cover is difficult to remove or replace, the left

122 8000 Operator’s Manual5 Maintenance and Troubleshooting 5 Press the printer toggle switch to the OnLine / Off Line position to stop the printing o

Maintenance and Troubleshooting 58000 Operator’s Manual 123 Obtaining Warranty and Other ServicesTo place a service order (warranty or other services)

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8000 Operator’s Manual 125 IndexNumerics8000clamp removal, 21unpacking, 21Aaspirt. dwell time, 56, 82Autocalibration Block, 37automatic calibration, 9

126 8000 Operator’s ManualIndex Rready screen, 35removing paper roll, 120replacement media (rm)installing external, 39installing internal, 38replaceme

Safety 18000 Operator’s Manual 13 WarningWARNINGA ‘Warning’ message appears in the manual when failure to observe instructions or precautions could re

14 8000 Operator’s Manual1Safety Information Symbols ISwitches main power on 0Switches main power offIndicates single-phase alternating currentI

15Agilent TechnologiesAgilent 8000 Dissolution Sampling StationOperator’s Manual 2Introduction8000 with Peristaltic Pump 17Conventions Used in this Ma

16 8000 Operator’s Manual2 Introduction The 8000 Dissolution Sampling Station provides an unattended solution for automated sampling from a dissolutio

Introduction 28000 Operator’s Manual 17 8000 with Peristaltic PumpThe 8000, when used in conjunction with the peristaltic pump, is capable of performi

18 8000 Operator’s Manual2 Introduction Serial Number FormatThe serial number contains 10 characters and follows this syntax:CC1234xxxxSyntax Code Mea

19Agilent TechnologiesAgilent 8000 Dissolution Sampling StationOperator’s Manual 3Setting Up the 8000Unpacking of 8000 and Components 20Setup of 8000

8000 Operator’s ManualNotices© Agilent Technologies, Inc. 2014No part of this manual may be reproduced in any form or by any means (including electron

20 8000 Operator’s Manual3 Setting Up the 8000 Unpacking of 8000 and ComponentsCheck the contents for any damages due to shipping. The packaging used

Setting Up the 8000 38000 Operator’s Manual 21 Unpacking Your 8000Figure 1 Agilent 8000 Dissolution Sampling StationThe 8000 is shipped in foam-filled

22 8000 Operator’s Manual3 Setting Up the 8000 Unpacking / Setup of 8000 & Peristaltic PumpEnvironmental Requirements for Peristaltic Pump Install

Setting Up the 8000 38000 Operator’s Manual 23 5 Loosely fit the peristaltic pump tubing along the inside groove of the first cartridge, locking the t

24 8000 Operator’s Manual3 Setting Up the 8000 apparatus:Figure 3 Cable Connections for 8000, Peristaltic Pump, and VK 7000 / 701011 Connect the five-

Setting Up the 8000 38000 Operator’s Manual 25 13 The 8000 is shipped with all sample tubing attached to the valves inside the dispensing arm. 14 If y

26 8000 Operator’s Manual3 Setting Up the 8000 16 Connect the remaining length of tubing coming from the top positions of the 8000 solenoid valves to

Setting Up the 8000 38000 Operator’s Manual 27 3 Place the 806 Syringe Pump on a clean, dry, level section of the bench top between the 8000 and the d

28 8000 Operator’s Manual3 Setting Up the 8000 8 A system configuration that includes a non-Agilent dissolution apparatus, requires use of an adapter

Setting Up the 8000 38000 Operator’s Manual 29 the 8000 solenoid valves. Ensure each line is attached to its identical color.12 Connect the remaining

8000 Operator’s Manual 3 ContentsFigures 7Tab les 91Safety 11Electrical Hazards 12Warning 13Caution 13Note 13Information Symbols 142 Introduction 1580

30 8000 Operator’s Manual3 Setting Up the 8000 InstallationFigure 8 808 Filter ChangerThe filter changer is shipped in individual packaging.1 Carefull

Setting Up the 8000 38000 Operator’s Manual 31 4 Refer to the following example diagram to correctly make cable connections for the 8000, syringe pump

32 8000 Operator’s Manual3 Setting Up the 8000 between the remaining extension of the Y cable attached to the syringe pump and the RS232 port on the d

Setting Up the 8000 38000 Operator’s Manual 33 starting with Position 1.Figure 11 Resident Probe Housing and Sample Cannula13 Connect a separate lengt

34 8000 Operator’s Manual3 Setting Up the 8000 Setup of 8000 and ComponentsInstalling 8000 Full Flow FiltersThe 8000 has been supplied with 10-, 35-,

Setting Up the 8000 38000 Operator’s Manual 35 • If your system configuration includes the syringe pump, the power receptacle, and power switch are lo

36 8000 Operator’s Manual3 Setting Up the 8000 Installing the Sample TrayPlace the supplied sample tray on top of the unit. The sample tray has four g

Setting Up the 8000 38000 Operator’s Manual 37 If your system configuration includes the peristaltic pump, complete the steps under “Installing and Co

38 8000 Operator’s Manual3 Setting Up the 8000 Installing the RM ModuleInternal UnitFigure 12 Internal Media Replacement Module1 Attach a length of 1/

Setting Up the 8000 38000 Operator’s Manual 39 External UnitFigure 13 External Media Replacement Module1 Remove the cover housing the RM chamber from

4 8000 Operator’s Manual ContentsInstalling the Media Rinse Reservoir 36Installing and Connecting the Autocalibration Block (Peristaltic Pump only) 37

40 8000 Operator’s Manual3 Setting Up the 8000 Loading Filters (Filter Changer only)1 Choose a tube of filters. Although you can load up to eight tube

Setting Up the 8000 38000 Operator’s Manual 41 10 Load the new tubes of filters into the carousel of the filter changer. See “Loading Filters (Filter

42 8000 Operator’s Manual3 Setting Up the 8000 MENU > 0 > D Use this key sequence to enable or disable the multiple sample option. The asterisk

Setting Up the 8000 38000 Operator’s Manual 43 This page was intentionally left blank, except for this message.

44 8000 Operator’s Manual3 Setting Up the 8000

45Agilent TechnologiesAgilent 8000 Dissolution Sampling StationOperator’s Manual 4Operating the 8000Operating the 8000 with Apparatus 1 / 2 46Operatin

46 8000 Operator’s Manual4 Operating the 8000 Operating the 8000 with Apparatus 1 / 28000 Keypad OptionsThe keypad on the 8000 is similar to a persona

Operating the 8000 48000 Operator’s Manual 47 The front panel options include the following:Table 2 Front Panel Options (Apparatus 1 / 2)Option Functi

48 8000 Operator’s Manual4 Operating the 8000 8000 Menu Options - Apparatus 1 / 2Main MenuFrom the Ready screen, press MENU. The Main Menu displays. O

Operating the 8000 48000 Operator’s Manual 49 Following is a description of the Main Menu screen options:Table 3 Main Menu Options (Apparatus 1 / 2)Op

Contents8000 Operator’s Manual 5 Syringe and Seal Replacement 112Cleaning the Syringes 113System Cleaning Procedure with Syringe Pump and Filter Chang

50 8000 Operator’s Manual4 Operating the 8000 4 Manual Prime Vol. (syringe pump)If your system configuration includes the syringe pump, use this optio

Operating the 8000 48000 Operator’s Manual 51 Main Menu Option 1 - Set Clock/AlarmsFrom the Main Menu, select option 1, Set Clock/Alarms. The Set Cloc

52 8000 Operator’s Manual4 Operating the 8000 4 Calib. Compl Alarm Use this option to set an alarm to sound when autocalibration is complete and all l

Operating the 8000 48000 Operator’s Manual 53 Main Menu Option 2 - Set DISSOFrom the Main Menu, select option 2, Set DISSO. Enter a program number and

54 8000 Operator’s Manual4 Operating the 8000 4 Set Bath Temp4 Vessel TempIf your system configuration includes a dissolution apparatus with a water b

Operating the 8000 48000 Operator’s Manual 55 Once all values have been entered, press ESC. A confirmation screen displays. Press Y to send the newly

56 8000 Operator’s Manual4 Operating the 8000 3 Prime Loss Volume Use this option to configure the prime loss volume. Prime loss volume compensates f

Operating the 8000 48000 Operator’s Manual 57 Main Menu Option 6 - Control DISSOFrom the Main Menu, select option 6, Control DISSO. The DISSO Control/

58 8000 Operator’s Manual4 Operating the 8000 The following Manual Operations screen displays when your system configuration includes the peristaltic

Operating the 8000 48000 Operator’s Manual 59 Manual Operation Option 6 - Syringe/FilterFrom the Manual Operations screen, select option 6, Syringe/Fi

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60 8000 Operator’s Manual4 Operating the 8000 3 Syringe Fill Use this option to draw a specific amount of medium into the syringes. Ensure the valve i

Operating the 8000 48000 Operator’s Manual 61 Creating a Sample Program 1 From the Ready screen, press PROG to program the 8000. 2 Enter a program num

62 8000 Operator’s Manual4 Operating the 8000 The following Program Variables screen displays when your system configuration includes the syringe pump

Operating the 8000 48000 Operator’s Manual 63 4 Headers Select option 4, Headers. The Batch # Selections screen displays. For each option, enter the d

64 8000 Operator’s Manual4 Operating the 8000 6 Purge Volume (syringe pump)If your system configuration includes the syringe pump, use this option to

Operating the 8000 48000 Operator’s Manual 65 Program Option 2 - Sample Time PointsFrom the Program Variables screen, select option 2, Sample Time Poi

66 8000 Operator’s Manual4 Operating the 8000 • If a shorter sample time point than the previous one is entered for a given row, the row number will n

Operating the 8000 48000 Operator’s Manual 67 3 To run a single program, select option 1.To link another program to the one previously selected, selec

68 8000 Operator’s Manual4 Operating the 8000 Following is a description of the Select Start Mode screen options:Table 11 Select Start Mode Options (A

Operating the 8000 48000 Operator’s Manual 69 DISSO Options ScreenFollowing is a description of the DISSO Options screen options:

8000 Operator’s Manual 7 FiguresFigure 1. Agilent 8000 Dissolution Sampling Station 21Figure 2. Peristaltic Pump 22Figure 3. Cable Connections for 800

70 8000 Operator’s Manual4 Operating the 8000 Select DISSO Program Start Mode Screen Following is a description of the Select DISSO Program Start Mode

Operating the 8000 48000 Operator’s Manual 71 Table 1 3 Select Disso Program Start Mode Options (Apparatus 1 / 2)Option Start Now Function Delayed Sta

72 8000 Operator’s Manual4 Operating the 8000 Operating the 8000 with Apparatus 3 / 78000 Keypad OptionsThe keypad on the 8000 is similar to a persona

Operating the 8000 48000 Operator’s Manual 73 The front panel options include the following:Table 1 4 Front Panel Options (Apparatus 3 / 7)Option Func

74 8000 Operator’s Manual4 Operating the 8000 8000 with Apparatus 3 / 7 - Menu OptionsMain Menu From the Ready screen, press MENU. The Main Menu displ

Operating the 8000 48000 Operator’s Manual 75 Following is a description of the Main Menu screen options:Table 1 5 Main Menu Options (Apparatus 3 / 7)

76 8000 Operator’s Manual4 Operating the 8000 4 Manual Prime Vol. (syringe pump)If your system configuration includes the syringe pump, use this optio

Operating the 8000 48000 Operator’s Manual 77 Main Menu Option 1 - Set Clock/AlarmsFrom the Main Menu, select option 1, Set Clock/Alarms. The Set Cloc

78 8000 Operator’s Manual4 Operating the 8000 4 Calib. Compl Alarm Use this option to set an alarm to sound when autocalibration is complete and all l

Operating the 8000 48000 Operator’s Manual 79 Main Menu Option 2 - Set APP 3/7From the Main Menu, select option 2, Set APP 3/7. Enter a program number

8 8000 Operator’s Manual FiguresThis page was intentionally left blank, except for this message.

80 8000 Operator’s Manual4 Operating the 8000 Once all values have been entered, press ESC. A confirmation screen displays. Press Y to send the newly

Operating the 8000 48000 Operator’s Manual 81 From the Main Menu, select option 3, Set Syringe Pump. Select option 2 to disable the syringe pump or se

82 8000 Operator’s Manual4 Operating the 8000 Main Menu Option 6 - Control APP 3/7From the Main Menu, select option 6, Control APP 3/7. The APP 3/7 Co

Operating the 8000 48000 Operator’s Manual 83 The following options are commands communicated from the 8000 to the Apparatus 3 / Apparatus 7:Press ESC

84 8000 Operator’s Manual4 Operating the 8000 Following is a description of the Manual Operations screen options:Manual Operation Option 6 Syringe/Fil

Operating the 8000 48000 Operator’s Manual 85 Following is a description of the Operate Syringe/Filter Changer screen options:Table 2 1 Operate Syring

86 8000 Operator’s Manual4 Operating the 8000 Creating a Sample Program1 From the Ready screen, press PROG to program the 8000. 2 Enter a program numb

Operating the 8000 48000 Operator’s Manual 87 The following Program Variables screen displays when your system configuration includes the peristaltic

88 8000 Operator’s Manual4 Operating the 8000 Following is a description of the Program Variables screen options:Table 2 2 Program Variables Options (

Operating the 8000 48000 Operator’s Manual 89 6 Purge Time (peristaltic pump)If your system configuration includes the peristaltic pump, use this opti

8000 Operator’s Manual 9 TablesTable 1. Hidden Key Functions 41Table 2. Front Panel Options (Apparatus 1 / 2) 47Table 3. Main Menu Options (Apparatus

90 8000 Operator’s Manual4 Operating the 8000 Program Option 2 - Sample Time PointsFrom the Program Variables screen, select option 2, Sample Time Poi

Operating the 8000 48000 Operator’s Manual 91 The following conventions are used with this screen:• Review previously entered sample time points by pr

92 8000 Operator’s Manual4 Operating the 8000 3 To run a single program, select option 1.To link another program to the one previously selected, selec

Operating the 8000 48000 Operator’s Manual 93 Following is a description of the Select Start Mode screen options:APP 3/7 Options Screen Following is

94 8000 Operator’s Manual4 Operating the 8000 Table 2 4 App 3/7 OptionsOption Start Now Function Delayed Start Function1 Load & Run APP 3/7Select

Operating the 8000 48000 Operator’s Manual 95 Manual SampleFrom the Ready screen, press MANUAL SAMPLE to collect a sample from the dissolution apparat

96 8000 Operator’s Manual4 Operating the 8000 3 Set Volume Select option 3, Set Volume. Enter a sample volume between 0 and 14 mL and press ENTER. The

Operating the 8000 48000 Operator’s Manual 97 Volumetric Calibration (Peristaltic Pump only)It is critical that sample volumes are accurately and prec

98 8000 Operator’s Manual4 Operating the 8000 5 The 8000 system monitor displays a reminder to ensure the tubing and pump are ready. The Calibrate Sam

Operating the 8000 48000 Operator’s Manual 99 Manual CalibrationTo perform the calibration yourself, complete the following steps:1 Remove the sample